… long-term inducible expression up to at least 5 years post gene transfer, with no any detectable
host immune response against the transactivator … recombinant adeno-associated virus …

… Recombinant AAV vectors have characteristics that make … These observations suggest that
additional long-term dose … such as the tetracycline-controlled transactivator (tTa) and reverse-…

… can lead to long-term expression in nonhuman primates but in … Many transactivators are
not derived from mammals and … be rejected by the immune system in humans in the long term; …

… of adeno-associated virus (AAV)-delivered transgenes, … transactivator protein for the Tet-On
transcriptional activation … of plasma Epo after the administration of recombinant protein 32,36 …

… Here we used an immune-evasive transactivator generated … short- and sustained long-term
GDNF expression in vivo in … intraspinal adeno-associated viral vector-mediated expression of …

… -controlled transactivator) from the immune system we … In this study, we compared the
long-term performance of the … Adeno-associated viral vector-mediated neurotrophin gene …

… recombinant Adeno-Associated Viruses (… long term inducible expression up to at least 5
years post-gene transfer with no any detectable host immune response against the transactivator …

… gene and cell therapy, such as adeno-associated virus (AAV), have intrinsic … ‘transactivator’
protein can trigger immune responses in … in vivo in a tunable manner with long-term stability. …

… control transgene expression in the absence of transactivators in … in expression, long-term
and rapid decrease of the desired … of this strategy used two adeno-associated vectors (AAVs), …

… the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated
transgene expression in … of recombinant adeno-associated virus. …